PLD: A Protein Involved in Cell Signaling and Disease Development

Target Name: Phospholipase D

NCBI ID: P11348

Phospholipase D

Other Name(s): None

PLD: A Protein Involved in Cell Signaling and Disease Development

Phospholipase D (PLD) is a protein that is involved in the process of breaking down phospholipids in cells. It is a critical enzyme that is involved in many different cellular processes, including the production of signals on cell surfaces, the regulation of cell growth, and the transport of molecules across cell membranes. PLD has also been shown to be involved in the development and progression of a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

PLD is a protein that is expressed in most tissues and cells in the body. It is a monomer that consists of a catalytic active site, a regulatory region, and a C-terminal region that is involved in protein-protein interactions. The catalytic active site is the region of the protein that catalyzes the breakdown of phospholipids, and it is the site where the protein interacts with other molecules to perform its function.

The regulation of PLD activity is controlled by a variety of factors, including the concentration ofPLD, the presence of inhibitors, and the overall level of cellular stress.PLD can be activated by various means, including the addition of inhibitors or the presence of stress molecules. Once PLD is activated, it catalyzes the breakdown of phospholipids, producing specialized lipids that can be used for signaling or energy production.

One of the key functions of PLD is its role in the production of signals on cell surfaces. Many signaling pathways rely on the delivery of small molecules, such as proteins or neurotransmitters, to the surface of cells. These molecules can interact with receptors on the surface of the cell, leading to changes in cellular behavior and the production of other signaling molecules. PLD is involved in the production of these signals by breaking down the phospholipids that make up the cell membrane and allowing the delivery of signaling molecules to the surface.

PLD is also involved in the regulation of cell growth and the transport of molecules across cell membranes. It has been shown to be involved in the production of cell wall materials, such as cellulose and chitin, which are involved in the structure and function of cells. PLD is also involved in the transport of molecules across cell membranes, such as ions and proteins, allowing it to play a role in the regulation of cellular homeostasis.

In addition to its role in cellular signaling and structure, PLD has also been shown to be involved in the development and progression of a variety of diseases. For example, PLD has been shown to be involved in the development of cancer, particularly breast cancer. Studies have shown that high levels of PLD activity are associated with the development of breast cancer, and that inhibitors of PLD can be used to treat this disease.

PLD has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to be the hallmark of these conditions. PLD has been shown to be involved in the production of these tangles, and inhibitors of PLD have been shown to be effective in treating these conditions.

Finally, PLD has also been shown to be involved in the development and progression of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. These conditions are characterized by the immune system attacking the body's own tissues, leading to inflammation and damage. PLD has been shown to be involved in the production of immune cells that contribute to these disorders, and inhibitors of PLD have been shown to be effective in treating these conditions.

In conclusion, PLD is a protein that is involved in a variety of cellular processes that are critical for the survival and proper functioning of cells. Its role in the production of signals on cell surfaces, the regulation of cell growth and the transport of molecules across cell membranes, and its involvement in the development and progression of a variety of diseases make it an attractive target for research and development. Further studies are needed to fully understand the mechanisms of PLD activity and its role in these diseases.

Protein Name: Phospholipase D (nonspecified Subtype)

The "Phospholipase D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Phospholipase D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets